DODAP (1,2-dioleoyl-3-dimethylammonium propane), Transfection Reagent

£86.45£608.00 Price ex. VAT

DODAP (1,2-dioleoyl-3-dimethylammonium propane)

Pack sizes : 25mg, 100mg ,  500mg

Send us an enquiry: parkinfo@parkscientific.com

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Description

CAS Number: 127512-29-2
Linear Formula: C41H77NO4
  • Key Features
  • High transfection efficiency and low cytotoxicity
  • Efficient delivery of plasmid DNA, siRNA/miRNA, and CRISPR/Cas9 components
  • Widely used in nanomedicine
  • Flexible and scalable

DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases.

Contact us at parkinfo@parkscientific.com to know about cGMP grade DODAP manufactured under 21 CFR part 210,211.

APPLICATION(S): DNA, SiRNA, mRNA transfection, Drug delivery, Gene therapy
SHIPPING REQUIREMENTS: Dry Ice
APPEARANCE: Colorless to light yellow liquid
MOLECULAR WEIGHT: 648.05
HANDLING: Protective gloves, safety glasses
STORAGE: -20°C

Additional information

Size

25 mg, 500 mg, 100 mg